[HTML][HTML] Intestinal permeability of metformin using single-pass intestinal perfusion in rats
NN Song, QS Li, CX Liu - World Journal of Gastroenterology: WJG, 2006 - ncbi.nlm.nih.gov
AIM: To characterize the intestinal transport and mechanism of metformin in rats and to
investigate whether or not metformin is a substrate for P-glycoprotein (P-gp). METHODS:
The effective intestinal permeability of metformin was investigated using single-pass
intestinal perfusion (SPIP) technique in male Waster rats. SPIP was performed in three
isolated intestinal segments (duodenum, jejunum and ileum) at the same concentration of
metformin (50 μg/mL) to test if the intestinal transport of metformin exhibited site-dependent …
investigate whether or not metformin is a substrate for P-glycoprotein (P-gp). METHODS:
The effective intestinal permeability of metformin was investigated using single-pass
intestinal perfusion (SPIP) technique in male Waster rats. SPIP was performed in three
isolated intestinal segments (duodenum, jejunum and ileum) at the same concentration of
metformin (50 μg/mL) to test if the intestinal transport of metformin exhibited site-dependent …
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